Question 1

How much do GLP-1 medications cost?

Accepted Answer

Brand-name Wegovy or Ozempic costs $900–$1,400 per month without insurance. Compounded semaglutide costs $250–$500 per month. Insurance coverage varies — many plans now cover GLP-1s for eligible patients with a BMI over 30.

Question 2

How much weight can I lose on Ozempic or Wegovy?

Accepted Answer

Clinical trials show average weight loss of 12–15% of body weight over one year with semaglutide. Tirzepatide (Mounjaro/Zepbound) shows even greater results at 15–22%. Individual results vary based on dosage, diet, and activity level.

Question 3

What are the side effects of GLP-1 medications?

Accepted Answer

Common side effects include nausea, vomiting, and gastrointestinal discomfort, especially during dose increases. These typically decrease over time. Serious but rare side effects include pancreatitis and thyroid concerns. Medical supervision is essential.

Question 4

Do I gain the weight back if I stop GLP-1 medication?

Accepted Answer

Studies show many patients regain weight after stopping GLP-1 medications without lifestyle changes. A comprehensive program that includes dietary changes, exercise, and behavioral modification helps maintain weight loss long-term.

Question 5

What's the difference between Ozempic, Wegovy, and Mounjaro?

Accepted Answer

All contain GLP-1 agonists. Ozempic and Wegovy both contain semaglutide — Wegovy is the higher-dose version FDA-approved for weight loss. Mounjaro contains tirzepatide, which targets two hormones (GLP-1 and GIP) and may produce greater weight loss. See our tirzepatide vs. semaglutide comparison for a full head-to-head breakdown.

Question 6

Which is more effective: tirzepatide or semaglutide?

Accepted Answer

Head-to-head trial data (SURMOUNT-5, published 2025) showed tirzepatide produced approximately 20% average body weight loss versus approximately 14% for semaglutide over 72 weeks. For most patients, tirzepatide produces more weight loss on average. Individual responses vary, and switching from one to the other is reasonable if the first does not work or is poorly tolerated.

Question 7

Is compounded semaglutide or tirzepatide safe?

Accepted Answer

Compounded versions are produced by licensed compounding pharmacies and are legal under FDA shortage rules. Compounded semaglutide typically costs $250–$500/month and compounded tirzepatide $400–$650/month — much less than brand-name. The FDA periodically removes either molecule from the official shortage list, which restricts compounding eligibility. Always verify your provider sources from a state-licensed compounding pharmacy.

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